Tapentadol is partly metabolized by the hepatic enzymes CYP2C9, CYP2C19, and CYP2D6 so it innately has interactions with medicines that increase or repress the action/expression of a number of of those enzymes, together with with substrates of those enzymes (because of Competitiveness to the enzyme); some enzyme mediators/substrates need dosing https://richardx420gkl3.wikilowdown.com/user