Analysis into conolidine has resulted in discovery of the opioid receptor in the human body referred to as ACKR3/CXCR7. ACKR3 seems to be the most sought after concentrate on for conolidine, which also disregards another 4 classical opioid receptors(3). **This is the subjective assessment according to the toughness from https://brooksvsiyl.pointblog.net/conoldine-alternative-natural-pain-relief-no-further-a-mystery-84736312