Custom made Orthoses may well assist to offload and redistribute your pounds effectively, minimizing strain and tension over the sesamoid bones though correcting problems with overpronation or oversupination.  5. Sesamoiditis Sesamoiditis is the inflammation of the two smaller bones located beneath the pad of the large toe, called the sesamoids. https://www.theorthopaedicandpainpractice.com/effective-treatments-for-ball-of-foot-pain/