You will find a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to lessen afferent soreness transmission and deliver analgesia. Therefore, medication like clonidine that goal alpha-two receptors can influence the transmission of ache. Clonidine is dispersed in breast milk; https://www.proleviate.com/post/the-new-pain-killer-conolidine