Summary: AAA+ proteins form asymmetric hexameric rings that hydrolyze ATP and thread substrate proteins through a central channel via mobile substrate-binding pore loops. Understanding how ATPase and threading activities are regulated and intertwined is key to understanding the AAA+ protein mechanism. We studied the disaggregase ClpB. which contains tandem ATPase domains (AAA1. https://www.jmannino.com/quick-save-Canon-imageCLASS-MF227dw-Monochrome-Multifunction-Laser-Printer-great-choice/