If a guardian from the proband is thought to have the pathogenic variant recognized from the proband, the risk towards the sibs of inheriting the pathogenic variant is 50%. As a consequence of lessened penetrance, sibs who inherit the pathogenic variant may or may not produce aHUS (see Penetrance). A https://waterchillers19753.mpeblog.com/57262322/detailed-notes-on-air-handling-units-ahus