The neurologic phenotype in SCA8 BAC expansion although not BAC Regulate strains demonstrated the pathogenicity with the (CTG-CAG)n expansion. Additionally, the expression of noncoding (CUG)n enlargement ATXN8OS transcripts and the discovery of intranuclear polyglutamine inclusions instructed that SCA8 pathogenesis requires harmful obtain-of-function mechanisms at both equally the pro... https://epz00477791111.blogs100.com/28742110/the-5-second-trick-for-ataxin-8-protein