Ecdysone and mediator modify energy metabolism to terminate proliferation in Drosophila neural stem cells. Mitochondrial fission for a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling. At the moment, TERT protein expression is getting used in making immortalize Principal cells http://servers.org.ua/user/mailstove79/